Aethlon Medical Inc (AEMD)

[ANESRI]

Exosomes in Gyn cancer

Semin Thromb Hemost 2010; 36(8): 925-929
DOI: 10.1055/s-0030-1267046

© Thieme Medical Publishers

Microparticles and Exosomes in Gynecologic Neoplasias

Rienk Nieuwland1, Joris A.M. van der Post2, Christianne A.R. Lok Gemma2, G. Kenter3, Augueste Sturk1
1 Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands
2 Department of Obstetrics and Gynaecology, Academic Medical Center, Amsterdam, The Netherlands
3 Department of Gynaecological Oncology, Academic Medical Center, Amsterdam, The Netherlands

ABSTRACT
This review presents an overview of the functions of microparticles and exosomes in gynecologic neoplasias. Growing evidence suggests that vesicles released from cancer cells in gynecologic malignancies contribute to the hypercoagulable state of these patients and contribute to tumor progression by suppressing the immune system, facilitating extracellular matrix degradation and removal of cytostatics from the tumor cell. Exosomes from ovarian carcinoma cells were shown to be present in peripheral blood and to augment tumor growth, suggesting that these vesicles directly support growth of tumor cells.