Aethlon Medical Inc (AEMD)

[ANESRI]

Sepsis and vascular dysfunction

Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction.
Gambim MH, do Carmo Ade O, Marti L, Veríssimo-Filho S, Lopes LR, Janiszewski M.
Source
Division of Rheumatology, University of São Paulo School of Medicine, Avenida Doutor Arnaldo, 455, 01246-903, São Paulo, SP. [e-mail]


CONCLUSION:
We showed that, in sepsis, NO and bacterial elements are responsible for type-specific platelet-derived exosome generation. Those exosomes have an active role in vascular signaling as redox-active particles that can induce endothelial cell caspase-3 activation and apoptosis by generating superoxide, NO and peroxynitrite. Thus, exosomes must be considered for further developments in understanding and treating vascular dysfunction in sepsis.

PMID: 17894858 [PubMed - indexed for MEDLINE] PMCID: PMC2556756