Pharmathene, Inc. (f/k/a PIP)

[cash2go]

siga-246

It is difficult to precisely define the potential contributions of each agent to the patient's recovery because of the close timing of administration. Vaccinia virus DNA levels in blood samples decreased from pretreatment levels following VIGIV and cidofovir treatment, then continued to decrease with the administration of ST-246, especially with achievement of target peak and trough ST-246 plasma concentration levels (figures 2B and 3). It appears that the patient mounted his own anti-orthopoxvirus IgG response between days 9 and 10; maximum IgG levels were achieved between hospital days 12 and 18 (figure 2A). Additionally complicating interpretation of the impact of individual interventions, we cannot yet differentiate between the patient's own IgG and that contributed by the VIGIV treatment. Although it is difficult to assess and differentiate the effects of specific therapeutic interventions, the child's immune response almost certainly played a role in the eventual control of his infection [16].

http://cid.oxfordjournals.org/content/46/10/1555.full

reminder that -246 is going to be purchased under BARDA.