NanoViricides Inc. (NNVC)

[FORZANANO]

DrFeelgood

Can you explain these two paragraphs:

Thank you.


In addition, we believe that the dengue virus infection was very well controlled in these treated animals. This is evidenced by the significant decrease in the level of the cytokine TNF-alpha in this nanoviricide-treated group, compared to control groups,” he further added.


In ADE, the very high levels of dengue virus in the body lead to a highly dysregulated immune response. This further leads to high levels of TNF-alpha and other inflammatory cytokines. These inflammatory cytokines subsequently play a role in the vascular leakage that is characteristic of severe dengue. In extreme cases, the vascular leakage can lead to potentially fatal hemorrhagic condition. Achieving control over the dengue virus level is generally expected to lead to control over the cytokine levels as well. Demonstration of control of cytokine levels is considered important in that it is generally believed that the cytokine level control will also lead to a controlled dengue disease that does not proceed to its severe states such as DHF.