EZ, I got killed in taxes in 2000 and 2001 when I had huge gains from 1999 and then the pennies started plummeting in 2000. It was a massacre as I had to sell-off to pay taxes. Now I mostly trade in a SEP IRA because I am self-employed and a Roth IRA. It's great. I never have to worry about taxes or finding where I bought a stock at. The only downside is you don't have access to your money if you need it without large penalties. With a Roth IRA you can take your principle out but you are limited to your maximum annual contribution.
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