Biotech Values

[iwfal]

Worst case would be that very rare mutations are the big driver - that people are tall (or short) for their own individual (but still inherited) genetic reasons.

Not trying to zing you but the first quote is exactly what the article was claiming was probably not true. The thesis of the article is that single mutations in a given individual, or even chains of mutations in that individual connected by an MOA (e.g. like the cascade of connected events in clotting), is probably NOT the cause most heritability.

Let's see what emerges from the 1,000 genome project before we throw up our hands and give up.

As I've said earlier in this thread, I agree that it is too early to write off traditional genetics and its influence on the missing heritibility (often 80-90 pct). BUT I'd also place even odds that >=50% of the missing heritibility is a result of a combo of 'other' factors. E.g.:

a) Epigenetics
b) Physical colocation of, say, a height gene next to a completely different and unrelated gene - where the unrelated gene is active so the height gene get transcribed more.