Dew, at what point will you drag yourself out of the all-oral HCV ditch and realize that the position is becoming more difficult to defend. Three drugs may work, but at what cost and at what risk of mounting side effects? In order to get a permanent remission or cure from HCV, the immune system needs to be engaged and that is what the interferon appears to do. The problem with the oral drugs is the vast number of viral particles that have to be inhibited to achieve remission, and the drugs that are designed to attack the viral proteins will also find targets on normal human proteins. It's a difficult design problem and while someone somewhere might come up with the right combo, eventually, it will be an expensive development program. Do yourself a favor and start thinking like a biologist and not an engineer.
