Not if you're properly taking profits on the way up. These stocks are so risky, not taking profits is suicide. You can't look at what could be. You have to look at what is. My first goal is to get my original cost out. That could be at a 100% gain so you're playing on for free on half of what you started. It's really up to you and your risk tolerance. You could ride the whole way up without selling at all. However, not knowing the technicals is like not having a battle plan.
Take GOIG for example. Topped out at .0096. The 200 day sma is where I decided was time to get all out. That was at .0093. I put my sell in at .0090. I did that because I knew some very simple technical analysis. You can say it means nothing to know it, but you would be wrong.
And at the very very least, if you don't buy technical analysis because you say its bogus, there are enough people that do follow it that it does become a self fulfilling prophecy in itself.