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Friday, 04/01/2005 2:27:28 AM

Friday, April 01, 2005 2:27:28 AM

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Patent Applications

We have filed claims for international and domestic patent protection. The patents, if issued, will help ensure protection of our bioinformatics platforms, analytical software, genome maps and genetic classifiers in forensic, consumer products, and pharmacogenomics applications. The most significant patent applications cover the bioinformatics platforms and genome maps. Other applications describe the mathematical process of finding complex genetic information and the actual processes that find the gene variants responsible for specific complex genetic traits.

Two of our patent applications, 'Compositions...Pigmentation' and 'Compositions...Statin', have entered National Phases and are pending review and we believe, approval in the U.S. and designated countries. The pigmentation patent is important because it includes the methods and compositions for determining skin shade, eye color or any other pigmentation application. Our Statin patent application includes the use of method for determining a person's ability to respond favorably to a particular Statin. We have covered all Statins and the use of our AIMs and any assay developed that might use those markers in the development of the assay.

Additional national phases will began for the other patents during the second quarter of 2004 and will likely run through 2005. As discoveries warrant, we will continue to apply for future additional patents. Listed below is our current patent pending applications.
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Pending Patent Applications

Efficient Methods and Apparatus for High-Throughput Processing of Gene Sequence Data US2003/0171875A1

Methods for the Identification of Genetic US2003/0171878A1
Features for Complex Genetics Classifiers WO 03/048318

Methods and Apparatus for use in Genetics Classification Including Classification Tree WO 03/048999
Analysis

Methods and Apparatus for use in Complex Genetics Classification WO 03/048372
Based on Correspondence Analysis and Linear-Quadratic Analysis

Composition and Methods for the Inference US10/156,995
Of Pigmentation Traits PCT/US02/16789
AU2002/312112
CA2,448,569
EP02739467.5
JP2003/500216

Compositions and Methods for Inferring US10/188,359
A Response to a Statin PCT/US02/20847
AU2002/316485
EP02746794.3
JP2003/509083

Single Nucleotide Polymorphisms and Combinations Thereof Predictive of PCT/US02/38345
Paclitaxel Responsiveness in Cancer Patients

Compositions and Methods for Inferring US10/644,594
Ancestry PCT/US03/26229