I think I should clarify that I'm not so much as afraid of bosutinib as concerned about the speed at which ariad can bring their drug to earlier treatment stages.
My pie-in-the-sky dream is that the next trial ARIA starts tomorrow is a head to head trial against imatinib / nilotinib / dasatinib (investigator's choice) in T315I mutation bearers only.
That could reasonably get ponatinib up to a part of the first line, and then ariad could have a reasonable claim with docs that if they don't have a mutation status report on their patients that they're better off starting them all on ponatinib.
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