This is a two-part study that will determine, if: 1) the combination of ridaforolimus and dalotuzumab will improve progression-free survival compared to exemestane; and 2) the combination of ridaforolimus and dalotuzumab will improve progression-free survival compared to both ridaforolimus and dalotuzumab as single agents, in participants with breast cancer.
Because it's a proof-of-concept study to test Merck's thesis that a combination study is more effective than a single agent dalotuzumab....or....single agent ridaforolimus.
Merck clearly wants to see a combination of Rida + Dalo (more revenues for them), and clearly, clinical evidence (in vivo and ex vivo)suggests that a combination of the two is much more likely to show stable disease over longer duration as well as partial response, than simply Dalo alone, or Rida alone.
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