CJ & Firefox, nice. One critical link on the way to market Cotara is insurance company reimbursement, and the need for rapid-shedding of the "experimental/investigational" label insurance companies hang around new drugs for an unconscienalble duration, refusing thus to pay for treatments.
Many oncologists will be called on to help annoint Cotara the "standard of care" for GBM, and oncologists are only one "pressure group" in only one arm of the mighty cancer treatment troyka: surgery, irradiation, and/or chemotherapy.
Cash flow is critical even deep within the rural pastures of physician offices...or luxury oncology treatment spas...and if a cut of the action from Cotara is not possible...medical doctors/providers will probably want to be in the grandstands cheering for this one. It would be decidedly bad PR to oppose an agent that has survived the trials Cotara has. The numbers are simply too good. Cotara technology is established imo. A new reality. Elegant logic suggested by overwhelming numbers. How long to the treatment table? We'll see. The next problem to solve with missile Cotara is bone marrow suppression if used systemically in tumorcidal doses. In single dose IV form, given to the level of bone marrow suppression, Cotara had no effect on Colon cancer progression. Therefore for effective systemic use mouse parts must be history in a hurry, and that's easy. We know how to make fully human Cotara. That's what the Epstein lawsuit was about, in part, and even though the are proably working on it 24-7 in China, and have the human-MAB recipe, Affitec in Europe, and PPHM in US, can produce human MAB Cotara in a heartbeat. A smaller missile? Fully humanized? Got it. Lower doses over a longer time period of time. Simple if fully human. And we know the dosing parameters, the maximal allowable dose to avoid systemic toxicity. Easy to use Cotara for imaging of tumors. Problem solved.
The message is clear: radioactive isotopes (RAI) borne on Cotara, a monoclonal antibody (MAB) missile that targets necrotic core of cancer, delivered with a special catheter that's tip is inserted into cancer bulk, is significantly effective in slowing the growth of the most resistant of cancers. Why target core cancer cells? Because the center of cancers contains a miasma of DNA and "sleeper" cancer cells capable of escaping externally delivered chemo-irradiation; regrouping; and recurring. So radioactive isotopes, specifically delivered, continue to perform as efficient cancer killers with minimal side effects.
As mentioned in previous posts, naked-Bavi will probably be used with Cotara to stimulate macrophage activity, and as armed Bavi perhaps carry a payload of RAI, in conjunction with Cotara. Core and cell surface. And then PPHM r84, a better Avastin to shut down the blood supply A triple smoke-out. More likely the next payload for all double-armed MAB missiles will be tTF, that small molecule PPHM gem that fits nicely onto both missiles.
And the next sensation, r84, PPHMs answer to Avastin has barely been mentioned here. R84 is cooking right now in Affitec reactors for use in clinical trials in the USSR. Shouldn't be much longer. PPHM seems to be in good shape.
AI
