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Tuesday, 10/26/2010 11:44:36 AM

Tuesday, October 26, 2010 11:44:36 AM

Post# of 7574
"It was found that our excipient was able to formulate small-size molecules either polar (hydrophilic such as metformin or ibuprofen) or non polar (as acetaminophen) as well as medium or large-size molecules such as bioactive peptides (ex. Nisin), proteins or even microorganisms (probiotics), essentially applying to many popular Over the Counter drugs and prescribed as well," stated Dr. Max Arella, CEO of the company.

However many of the delivery technologies for therapeutic peptides or proteins failed to overcome three major obstacles: i) Denaturation of the peptide or of the protein or bacterium by gastric acid and even by pepsin protease in the stomach environment, ii) Degradation of the peptide or protein or bacterium by the attack of proteolytic enzymes in intestine, iii) poor or limited absorption of the peptide or protein into the bloodstream (if not directed to the colon).