Tuesday, October 26, 2010 11:44:36 AM
However many of the delivery technologies for therapeutic peptides or proteins failed to overcome three major obstacles: i) Denaturation of the peptide or of the protein or bacterium by gastric acid and even by pepsin protease in the stomach environment, ii) Degradation of the peptide or protein or bacterium by the attack of proteolytic enzymes in intestine, iii) poor or limited absorption of the peptide or protein into the bloodstream (if not directed to the colon).
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