CytoSorbents Corporation (CTSO)

[jdupriest]

"INFLAMMATORY MEDIATORS OF INTEREST"...(page7) "In our laboratory, three important cytokine mediators of sepsis to be studied were chosen
based on data from the largest sepsis study to date, the results of an observational study called
GenIMS at the University Of Pittsburgh School Of Medicine, Department of Critical Care. This
study, which analyzed more than 1600 patients at 30 sites in the Eastern United States, found that
plasma levels of interleukin 6 (IL-6), tumor necrosis factor (TNF), and interleukin 10 (IL-10) on
the day of presentation were higher in those patients that died in the hospital compared to those
that were discharged alive [17]. A conclusion of the GenIMS study was that those three
cytokines were important for predicting outcomes in sepsis and were, therefore, significant to
modulate using hemoadsorption (discussed in section 1.4.1) [17]".
http://etd.library.pitt.edu/ETD/available/etd-07222010-191334/unrestricted/Valenti_MS_2010.pdf