NanoViricides Inc. (NNVC)

[BonelessCat]

A new poster to the thread had dozens of errors in the discussion, too many to really do justice without wasting an enormous amount of time. The errors I want to point out in this post are the contention that mouse models don't reflect human testing. This is absolutely false.

Since the mid-1990s the SCID-hu Thy/Liv mouse model has been the standard for HIV testing specifically because it is such an accurate predictor for human testing. The CDC, NIH and FDA all recognize the SCID-hu Thy/Liv murine as an accurate predictor as a test subject pre-clinical work. For a drug such as HIV-Cide, a drug that sweeps HIV particles in the blood, the model is an even more accurate indicator for viral load reduction, which was reported as functionally zero. Moreover, the model excellently represents impact on CD-4 and CD-8 cells, which again were reported as having viral matter reduction following HIC-Cide treatment.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC163193/
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000655

Similarly, the AG129 model for Dengue has been in use since 1998 and over the past 7 years has demonstrated close parallels to human reactions and outcomes to Dengue infections. Again, it is an excellent predictor for humans and all four Dengue types. The problem with Dengue isn't that the mouse models are inaccurate; it's that the vaccines are unstable in the field. So, in the lab all is fine, but start producing thousands of doses for clinical field work and that is when the Dengue vaccine issues begin to show, issues completely unrelated to mouse/human testing.

http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.05057.x/pdf

Herpes virus testing and Hep C also have accurate murine models. The Hep C mouse model has been in use since 2006, while the HSV mouse model has been around about 10 years longer. Although neither have established standard mouse strains for testing, those in use yield data that closely characterize expected human results.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1610068/
http://www.ncbi.nlm.nih.gov/pubmed/1664131