Monday, September 20, 2010 11:24:24 AM
NOTE: VHF and HVF are the same thing.
http://www.cdc.gov/ncidod/dvrd/spb/mnpages/dispages/vhf.htm
PR 7-23-07: Pending Contract from DOD for AntiPS vs. Hemorrhagic Fevers
“Peregrine Enters Contract Negotiations With U.S. DTRA for Hemorrhagic Fevers - U.S. Dept. of Defense Agency Has Selected Peregrine for a Multi-Year Award That Could Total $44.5mm Pending Successful Contract Negotiations”
http://www.peregrineinc.com/content.php?mi=MTc=&appAction=--PRINT&Id=MTAyOTM0Mw
TUSTIN, CA., July 23 1007: Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM), a clinical stage biopharmaceutical company developing monoclonal antibodies for the treatment of cancer and hepatitis C virus (HCV) infection, today announced that the company's proposal to investigate its antiviral agent bavituximab and other anti-phosphotidylserine (anti-PS) antibodies as potential therapies for hemorrhagic fever virus (HFV) infections has been selected for a contract award by the Defense Threat Reduction Agency (DTRA) of the U.S. Dept. of Defense (DOD), pending negotiation of a final contract. In its notification announcing the selection of Peregrine's proposal, DTRA stated that its goal is to finalize the contract award within the next few months.
How are hemorrhagic fever viruses grouped?
VHFs are caused by viruses of four distinct families: arenaviruses, filoviruses, bunyaviruses, and flaviviruses. Each of these families share a number of features:
They are all RNA viruses, and all are covered, or enveloped, in a fatty (lipid) coating.
Their survival is dependent on an animal or insect host, called the natural reservoir.
The viruses are geographically restricted to the areas where their host species live.
Humans are not the natural reservoir for any of these viruses. Humans are infected when they come into contact with infected hosts. However, with some viruses, after the accidental transmission from the host, humans can transmit the virus to one another.
Human cases or outbreaks of hemorrhagic fevers caused by these viruses occur sporadically and irregularly. The occurrence of outbreaks cannot be easily predicted.
With a few noteworthy exceptions, there is no cure or established drug treatment for VHFs.
In rare cases, other viral and bacterial infections can cause a hemorrhagic fever; scrub typhus is a good example.
http://www.cdc.gov/ncidod/dvrd/spb/mnpages/dispages/vhf.htm
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