InternistMD...I stand corrected, I thought the new panzem utilized passive targeting........ 3. Passive targeting Passive targeting is technology used to accumulate drugs on the target regions, which stimulates living bodies' functions by increasing stability in the body during the process whereby the drugs dosage exerts its effect. Enhanced Permeability and Retention EffectLow molecular weight drugs permeate through the blood capillaries and reach all organs in varying degrees. Materials made up of less than 30,000 molecules quickly get discharged from bodies after renal glomerular filteration. By multiplying themselves, cancer tissues cause production of new vessels with poor structural ability. The blood permeability surrunding the cancer tissue is as large as three to ten times compared to the normal tissue because of the dysfunction of the blood and the presense of VEGF. Therefore, polymer molecules and nanoparticles easily permeate and accumulate in cancer tissues. Furthermore, lymph vessels of cancer tissues are immature or absent. In general, while leaked polymer molecules or nanoparticles in normal tissues move to lymph vessels and get discharged, they remain for a long time in cancer tissues after the leakage. As a result, polymer molecules and micro particles have a tendency to accumulate around cancer tissues, which means that anti-cancer drugs if maintained stably within micellar nanoparticles would accumulate on cancer tissues.
