O3 destroys the outer lipid membranes of bacteria and (presumably) viruses. Bacterial resistance is generated via multiple pathways usually involving the DNA (chromosomal material) of the bug. To the best of my knowledge no micro-organism can mutate to make the outer lipid (fatty) membrane resistant to O3 activity. This is why MZEI's approach is radically different and so effective.
Another note: drug resistant TB is a major threat to world health. MZEI needs to do some TB trials similar to those done last spring on MRSA, Clostridium, etc. My prediction is that the lipid membrane of TB would go poof! and the bug would die.
About the role of agricultural antibiotics: one study in the last few years indicated that N. Carolina hog and chicken farms used more antibiotics than the entire hospitalized population of the U.S. These farms-and also major teaching hospitals-have therefore become sources of resistant bugs.
Moral: if you need surgery, try to have it as an outpatient if possible.
This company's technology is very important and has unlimited potential (international flights, sports facilities, schools, clinics, breeding farms for chicken, pigs, beef, etc.)
