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Wednesday, June 30, 2010 7:33:48 AM
CTSO engineers are really great minds: read:
"The article focuses more in general on the potential of size exclusion chromatography such as gel electophoresis for example as analytical tool to determine properties of different substances and as a seperation technique. Cytosorb works with the same principle by controlling the concentration of the polimer beads within the cartridge.thus allowing for different size of the pores so certain of the substances within the blood which flows through the cartridge will delay and wouldn't enough for themto exit and pump back into the patient.
One point to mention related to the article is that this separation is done not entirely by site or weight but the shape of the proteins as well.(although most of the protein in the blood are globulins which are round shaped like.
But if for exmaple we would like to separate diffrent DNA/RNA molecules(gel elctrophoresis) the shape of the DNA(such as supercoiled,coiled,linear... depends also if it's in relax/tension condition and so on... will not get into it) will determine it's mobility in the stationary phase.
Anyway size exclusion chromatography is used with a wide variety of implementations and very powerful. this subject coudn't be covered with even an entire book and require alot of background information and experience in the lab."
quote from memeil26 yahoo message board 30-jun-2010
http://seekingalpha.com/instablog/399559-chemistfrog/78833-cytosorb-is-a-novel-application-of-tried-and-true-technology
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