In yesterday's presentation one thing I hadn't heard before is that 50% of Sprycel and Tasigna patients eventually progress. Tasigna and Sprycel combined currently generate $600mm in sales, however, that could grow significantly in coming years. And, with Gleevec coming off patent in 2015, Sprycel and Tasigna are already jockeying for first-line treatment approval which in turn would position AP534 as the defacto second line therapy.
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