Biotech Values

[DewDiligence]

When patients take telaprevir, it kills off the normal, unmutated viral particles. The few mutants that are resistant grow in number and become increasingly hard to kill… as many as 20 percent of viral particles became resistant to Vertex’s telaprevir within two days of taking it, according to researchers…

The rapid onset of resistance is a feature of HCV protease inhibitors in general, not just Telaprevir. These drugs clearly can't be used as monotherapy.