Sirtris’ IP estate included a number of analogs. If the safety problem with SRT501 is compound-specific, the sirtuin program could still bear fruit. On the other hand, if the problem with SRT501 is mechanistic, GSK wasted a lot of money. For what GSK paid to acquire Sirtris, they could have bought IDIX (instead of partnering with them).
“The efficient-market hypothesis may be
the foremost piece of B.S. ever promulgated
in any area of human knowledge!”