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Re: rkrw post# 94555

Wednesday, 04/21/2010 12:57:05 PM

Wednesday, April 21, 2010 12:57:05 PM

Post# of 252319
Erbitux wasn't one of the 4 drugs tested in the BATTLE program but at least one study concludes "In contrast with colorectal cancer, and within the limitations of the data set, efficacy parameters did not appear to correlate with K-Ras mutation status or with any of the EGFR-related biomarkers evaluated. Additional exploratory analyses are essential to identify predictive markers and to optimize patient selection for cetuximab therapy in NSCLC."

http://jco.ascopubs.org/cgi/content/abstract/28/6/918

Edit
Found another:

"Conclusions: These data suggest that KRAS mutations may not play a significant predictive role for cetuximab-based therapy in NSCLC, contrary to colorectal cancer."

http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=65&abstractID=33350

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