Oncolytics Biotech Inc. (ONCY): Molecular pathways associated with Reoly...

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Re: surf1944 post# 168

Wednesday, 04/14/2010 10:56:06 PM

Wednesday, April 14, 2010 10:56:06 PM

Molecular pathways associated with Reolysin and gemcitabine synergy in ras-mutated human HCT116 cells – AACR 2010 Abstract #1646

http://media.integratir.com/T.ONC/ppt/1646_M_Lane_Colorectal_Gem.pdf

Work done by the Albert Einstein College of Medicine

covers work done to better understand the mechanisms associated with the cytotoxic synergies in this combined approach.

The investigators concluded that the top three canonical pathways significantly affected by the combination treatment were interferon signaling, antigen presentation and the protein ubiquitination pathways.

These data suggest that the combination of gemcitabine and REOLYSIN stimulates the immune system to increase surveillance/recognition of cancer cells.

The poster is scheduled to be presented on Monday, April 19, 2010.

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