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Post# of 623737
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Gatorelf

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Gatorelf

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Re: mick post# 199001

Monday, 03/22/2010 8:19:34 AM

Monday, March 22, 2010 8:19:34 AM

Post# of 623737
Pazdur is taking a very hard line against pixantrone in his opening remarks. The major concerns:

1. Is there "substantial evidence" of pixantrone's efficacy?
2. Are these results generalizable to the U.S. patient population?
3. Is pixantrone safe in light of increased rates of cardiotoxicity and febrile neutropenia in the pixantrone-treated arm?

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