RespireRx Pharmaceuticals Inc (RSPI)

[neuroinv]

Excellent point. I don't know what the higher-risk subgroups might be, I'd suspect obesity,cardio problems,sleep apnea (correlated with obesity), age, but it's not my area. I'd been thinking about Entereg for preventing postoperative ileus, but I gather the incidence there is close to 50%.

So one would have to identify a higher risk subgroup where RD is less rare, and thus prophylaxis justified. I'd wonder what incidence base rate would be seen as sufficient--could one parse out a subgroup with a 25% incidence rate, and without taking it to an absurd level of specificity? ('trial will enroll only patients with a BMI of over 35, who are over 75 years of age, have a history myocardial infarction, and have been diagnosed with OSA...')

NeuroInvestment