Newcardio, Inc. (NWCI)

[califax]

Visual3Dx™ -

http://www.newcardio.com/products-visual-ecg.php

Although diagnostically valuable, the standard 12-lead ECG has significant limitations. The ECG is a 2-dimensional representation of cardiac electrical activity, an inherently 3-dimensional event. As a consequence, significant amounts of important information are not used because the human mind is not capable of synthesizing all of this complex information. In addition, errors in interpreting the standard 12-lead ECG are common and can lead to serious clinical mismanagement. Errors of “major proportions” have been identified in 4% to 32% of ECG interpretations. The fear of wrong diagnoses and the associated legal liability results in many unnecessary admissions to hospitals of patients with chest pain. Many independent estimates put the cost of these unnecessary admissions in the US at well over $5 billion. New analysis approaches are urgently needed to reduce interpretative error and to improve diagnostic accuracy.

Visual3Dx™ Software

Visual3Dx™ is a set of algorithms and tools that provide a comprehensive method to describe cardiac electrical activity in time and space. Visual3Dx™ extracts additional information from standard 12-lead ECG signals and uses it to generate a 3D representation of cardiac electrical activity as a function of time. To further enhance understanding and ease of use, the program superimposes the diagnostically relevant electrical information on an intuitive, revolving 3-D anatomic model of the heart.

A key aspect of Visual3Dx™ is its suite of algorithms to correct the problem of variation in electrical attenuation across the chest wall. This leads to regional inconsistency and poor diagnostic sensitivity in remote regions of the heart. To correct this problem, Visual3Dx™ includes algorithms to normalize electrical attenuation, which results in a "virtual sphere" of normalized electrical activity, and ensures accurate and balanced representation of all heart regions.

We believe Visual3Dx’s features enable it to detect serious cardiac diseases with far greater sensitivity and specificity than is possible with a standard ECG. Importantly, however, Visual3Dx™ requires no change in standard 12-lead ECG practice. The ECG is obtained exactly as it is now, with the electrodes placed in the same locations without need for additional electrodes. Moreover, Visual3Dx™ displays the standard 12-lead ECG along with its novel 3-D analytical presentations. This allows the physician to make correlations between displays and provides reassurance that no information has been lost.


A typical Visual3Dx™ output that is easy to read and thus requires less training to interpret, when compared with the standard 12-lead display.