Back from when I followed OMRI until it was munched by JNJ
Thrombin stand-alone is intended for cases, such as certain types of neurosurgery, where the physician desires a more gradual onset of clotting than that provided by standard fibrin sealants. OMRI expected that the standalone thrombin market over time will remain flat or decrease in favor of thrombin-enhanced hemostats (including flowables). OMRI also expected fibrin patch to be the next big thing (I also got positive comments at that time from a trauma surgeon on the broad utility for the product). Edit: just found this slide from OMRI's presentation on convergence product
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