Avid Bioservices Inc (CDMO)

[entdoc]

sunstar, agreed. Treatment with PPHMs Bavituximab appears to improve patient immune response to re-implantation of the same tumor, a phenomenon consistant with what we know about the immune system's capability once the failure to recognize tumor as foreign is unblocked. It appears that surface PS is the culprit, and Bavi's ability to couple with PS and block its deleterious effects allows an amplified response to the cancer. It will be interesting to see the virus/cancer tie-in elucidated via this mechanism. It will also be interesting when we can make use of immunization techniques using Bavi + "neutered" cancer cells (like live attenuated virus vaccines)to further enhance immune response. It's beginning to look like Bavi+irradiation is the way to go. Too bad that avenue was not available when we started PII trials with chemo. Imagine what Bavi's punch would be in early disease when the immune system has not already been poisoned by chemo.