Genta, Inc (fka GNTAQ)

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◆ This article from the Beijing Academy of Traditional Chinese Medicine Jinkui
Time: 2009-11-07 13:11 Source: Author: Click: 13 Times
Biopharmaceutical company Genta's antisense agent Genasense (TM) enhances the breast cancer chemotherapy drugs& nbsp Genta bio-pharmaceutical companies, scientists at the joint use of the company's anti-sense agent Genasense (TM) products and chemotherapy drugs doxorubicin treatment on mice and achieved a GOOD therapeutic effect.

As the Genasense is through acting on a kind of tumor called Bcl-2 proteins play a role, so in previous studies, scientists always choose those that highly expressed Bcl-2 protein in cancer cells to do testing. In the experiment, scientists deliberately selected a number of relatively low degree of expression of Bcl-2 protein in cancer cells to observe the Genasense in these cells to conventional chemotherapy for the degree of influence. The results showed that low expression of Bcl-2 protein in cancer cells by the Genasense pretreatment, the same right and then given doxorubicin chemotherapy had a high degree of sensitivity.

Studies have shown that, Genasense does not affect the blood concentrations of adriamycin. If you use a non-Bcl-2 protein-specific anti-sense agents to carry out pre-processing of the cancer cells will not produce this "chemotherapy sensitization" effect.

This shows that, Genasense this "chemotherapy allergenicity," both for the high or low degree of expression of Bcl-2 protein in cancer cells are VALID, which has a VERY BROAD clinical application.

http://translate.google.com/translate?hl=en&sl=zh-CN&u=http://www.767.org.cn/html/ruxianzengshengruxianai/20091107/1524.html&ei=mj32Su22LI-

PEACE
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