On CNS side effects of VVUS drug, I've posted similar thoughts (http://siliconinvestor.advfn.com/readmsg.aspx?msgid=26052980). Safety profile looks approvable to me although the FDA will probably ask for a panel review as well as REMS program, especially since obesity drugs are expected to be overused. Other problems I see for VVUS are reimbursement (that goes for all obesity branded drugs), use of Qnexa's generic components, and possible IP issue with JNJ.
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