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Re: dia76ca post# 39665

Sunday, 08/02/2009 6:41:06 PM

Sunday, August 02, 2009 6:41:06 PM

Post# of 346146
dia, I suppose more specificity is what's happening: Tissue factor (TF) is a potent thrombosis-inducing agent that, tamed a bit, may be used for severe bleeding (read hemophelia). However, TF has obvious deleterious effects in normals even though it binds to PS. How to get it to cancer PS?
Tear TF apart at appropriate intervals...prune the branches so to speak...design a branch or coupling to fit a two-fisted MAB missile that is safe (!), and may be targeted only to cancer tumor vessel lining...and the vicious clotting cascade begins. How much longer can the roche hide behind avastin?! I say give 'em Cotara..then Bavi..and for dessert an anti-EGF to further discourage local stragglers and recurrence.
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