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Thursday, 09/09/2004 8:10:54 PM

Thursday, September 09, 2004 8:10:54 PM

Post# of 252388
transgenic fish - Fish to help stem severe bleeding


Scientists have used GM fish to produce a blood clotting agent
A fish could be used to produce a treatment for people with haemophilia and gunshot wounds, scientists believe.
Researchers have already made a blood clotting agent, known as factor VII, from genetically modified tilapia, a freshwater fish farmed for food.

As well as being used to treat a rare form of haemophilia, factor VII can also be used to stem internal bleeding.

The research is being carried out by the University of Southampton and US experts, the New Scientist reports.


Factor VII is already produced using hamster cells but the cost of a single injection can be as high as £6,000.

It is used to treat a rare form of haemophilia, sometimes known as Alexander's disease, and for people with the more common haemophilia A and B who reject traditional forms of treatment.

Soldiers

But the protein has also been used by soldiers to stem bleeding caused by accidents and gunshot wounds.

Professor Norman Maclean of the University of Southampton, who led the research, told BBC News Online he was hoping to produce the protein for about a tenth of the current price.

The project, which is being run in conjunction with the Florida bio-tech firm AquaGene, has produced the protein by adding a human gene to the fish, which then excretes the factor VII into its blood.

The protein is then removed from the blood and transferred into humans.

He said: "It works by forming clots when someone has internal bleeding.

"The form of haemophilia it could treat is quite rare so I think the largest benefit will come from treating crash victims and people with gunshot wounds who have severe internal bleeding."

Prof Maclean said he also believed fish could be used to treat other diseases.

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