Just to set the record straight. No maxy gene shuffled program ever reached phase 2.
I had forgot about maxy-alpha getting into p1. This is their only internally invented maxy shuffled compound to have entered the clinic. Study halted early in phase 1a, placed on hold.
Maxygen Announces Hold on MAXY-alpha Development Program
REDWOOD CITY, Calif., September 21, 2007—Roche has advised Maxygen, Inc. (Nasdaq: MAXY) that it has voluntarily placed a hold on further clinical development of MAXY-alpha, also known as R7025. MAXY-alpha is a novel interferon-alpha for the treatment of Hepatitis C and Hepatitis B virus infections and is licensed to Roche.
Preliminary observations from a Phase I trial indicate that an unexpected reduction of the pharmacodynamic and pharmacokinetic effects of MAXY-alpha occurred in the majority of subjects who received two doses of MAXY-alpha. In addition, antibodies binding to MAXY-alpha were identified in some subjects. Roche has initiated additional investigational studies in order to assess these results.
“We are all surprised by these unexpected findings,” said Russell Howard, Maxygen’s chief executive officer. “We don’t yet know how this will impact the future timing or advancement of the program. Roche has now started additional work to assess the meaning and significance of these results. We will provide an update once all relevant information is collected and evaluated.”
Well the timing was that the partnership was terminated less than 2 months later.
That's it, one gene shuffled compound entering the clinic in their 12+ year existence. I guess if they had it over again they would have spun off the therapeutic arm and kept Codexis and everything else.
