Biotech Values

[tinkershaw]

<<<The pramlintide/leptin phase IIa trial enrolled overweight and obese patients with a BMI of 27-35 kg/m2. Think this subgroup might be too 'light' to tolerate 2xday injections.>>>

That is an initial reflex consideration. However, consider what people actually go through to lose weight. I would not be surprised to see models and celebrities and high brow who have access to such stuff clamoring for a drug like this that they can inject that will help them keep the weight off.

People literally starve themselves nearly to death to lose weight. Two pin pricks a day won't get in the way.

The sad thing is that it won't get in the way of someone trying to fit into their bikini but it might be too much for an obese person in the intended group of 27-35 kg/m2.

You know darn well Britney Spears would be on pramlintide/leptin if she could get her hands on it and it would become the "cool" and "in" diet drug.

Again though, not necessarily for the intended patient population for whom I think you might be correct. They may or may not take to two pricks a day. Depends on how big the pin prick will be for one thing. The size of the pin prick won't matter to Britney and her ilk, but it will matter a heck of a lot to obese people in the 27-35 range.

A little faith however, I doubt AMLN would continue to push this drug forward if the required needle size was too onerous to make a potentially commerically successful product. Then again....

More info needed.

Tinker