Biotech Values

[drbio45]

two for the price of one; PML and brain cancer
ABSTRACT
Title: Primary central nervous system lymphoma in a patient treated with natalizumab

Abstract:
A 40 year-old man with relapsing-remitting multiple sclerosis (MS) developed primary central nervous system lymphoma (PCNSL) after having received 21 doses of natalizumab monotherapy. PCNSL is a disease of the elderly, with the majority of patients being diagnosed in the seventh to eighth decade of life. Immunodeficiency, iatrogenic immunosuppression and some autoimmune diseases are known as predisposing conditions, and in these patients PCNSL peaks in forth decade. Since there is no increased prevalence of PCNSL in MS and the patient was otherwise not immunocompromised, an association between natalizumab therapy and PCNSL cannot be ruled out. Ann Neurol 2009.