Biotech Values

[poorgradstudent]

I'll take a stab...

For smooth muscle cells that line vessels, charged compounds (as I understand macugen to be underneath its PEG clothing) can and do cause them to contract. Smooth muscles can maintain stress almost indefinitely (which may relate to the clot issue mentioned). However, innervating smooth muscles to maintain stress will cause them to hypertrophy (get larger) as well as proliferate. I'd bet that at the higher dose, they're getting proliferation of smooth muscle cells that is counter-productive to their desired physiological. The hypertrophy and proliferation of smooth muscle cells is also likely to be a primary contributing factor to any fibrosis that may take place, if we believe a certain biotech ceo.