Biotech Values

[rph_in_wi]

Re: Tamoxifen and genetic links to Drug Interactions.

Dew,

The science of this interaction goes back to at least 2002, but mostly from 2007. This is not new and my database shows this as an interaction to "avoid concurrent use". This is based on decreased CYP2D6 activity either by "genetic varients and/or drug interaction". The decrease in activity of Tamoxifen is associated with decreased concentrations of the highly active metabolites of Tamoxifen. I could try to find the links to the studies if they are of interest.

The more interesting question is why is Medco studying this. Remember, I believe they are evil so there must be something in it for them. Medco has started offering a genetic test for all Tamoxifen patients paid for by the sponsor. That right, for $250.00 a pop, Medco will check for the genetic marker that is related to Tamoxifen efficacy. If they prove that CYP2D6 effects the efficacy, then more people will want to test their employees for this genetic marker. The sponsor wants the best outcome for the money for it's employees so many would be willing to pay for this service. Especially if there is "science" behind it.

That's my take. You can decide if they are evil!!

RPh