hogs, major innovation is a very hard thing to predict, and bubbles are too!
If I had to guess for the source of world-changing innovation it would be something in genetics/bio or energy. I don't know how to make investment decisions based on this sort of thinking, though.
If I had to guess the next bubble, I would guess gold. I am fairly certain that the next bubble will not be financials, emerging markets, bonds, real estate, base metals, or oil, since those markets all just had bubbles pop recently.