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Re: tony111 post# 76542

Saturday, 04/25/2009 10:18:30 AM

Saturday, April 25, 2009 10:18:30 AM

Post# of 252009

Given that RVR is a good indication of SVR and that Rib significantly increases SVR, I would think adding Rib to interferon also increases RVR. If thats the case, then you would think Rib should play a role in early viral kinetics. However, I can't find data to support that hypothesis.



Just to close out this thread there are at least two separate papers indicating that this is, in fact, not true. Rib does not add to early response when combined with ifn-a - it kicks in later in preventing breakthrough and preventing relapse.

See ivillage site for details.

Note that this is interesting given that the logic you extoll above is reasonable - perhaps it is because rvr has a smaller false negative than false positive? (I do not actually know this is true - but suspect it)

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