Emenem,
I know that you have expressed continued skepticism of ampakine effectiveness in SA. I still disagree with the significance of your concerns, even if ampakines promote alertness at the dosages required for effective treatment of SA. First, I would not be surprised to find that the effective dosage is very variable from individual to individual. This would be no different than for many, many other drugs in a huge range of indications - omeprasole, Adderal, Paxil, warfarin, asprin, benadryl, etc., etc., etc. Secondly, the human body can be quite adaptive, especially if there is a strong motive. Not wearing a CPAP mask would be a pretty strong motive for me, and probably for most people to give the drug a chance. To support this, remember in our last exchange on this subject I mentioned that caffeine now (now that I am an old guy...) kept me from falling asleep because of all the stimulant effects. I wondered if I could get used to even these very uncomfortable sensations when trying to fall asleep. So, an hour or so every night before going to bed I drank caffeinated stuff (tea, coffee, soda). For the first few days, I had trouble falling asleep, though I never stayed awake for more than an hour or so. But, after only a few days, even though I still had the caffeine induced symptoms, I could fall asleep pretty quickly. That is pretty crappy antidotal evidence, and maybe I was only building up some kind of resistance to the caffeine, but why wouldn't something similar be true for an ampakine? I'd like to volunteer to find out!
Just my opinion.
Finally, don't get me wrong - I'm as unhappy with my investment in COR as the next guy. I think that the company has been fending off buyout offers that any of us would be happy to accept, but because of the depth of their underwater options, they have been unwilling to consider them. It is unclear to me what would happen if a company would come out with a buyout offer presented to the shareholders, but COR would likely use it as an opportunity to sell more shares and continue to swing for the fences. I just hope that some DH finally makes contact!
