Thursday, February 19, 2009 9:25:26 PM
So when dosing at 1000 mg or more, CX-717 will likely produce some insomnia. Additional insights can be gleaned from the ADHD trial, which dosed up to 800 mg twice/day, with 34% of patients at the high dose having insomnia (compared to 13% of patients on placebo).
But how high would dosing need to be to treat Sleep Apnea? Using RD as a guide, while we went up as high as 2100 mg in RD-2, and 1500 mg was used in RD-1, it was later revealed that the 900 mg cohort in RD-2 worked just as well as the 1500 mg dose in RD-1 (as measured by improvement in VE-55, see slide 8 from 11-10-08). However, even if the ideal therapeutic dose in RD turned out to be only 900 mg, and assuming RD is an accurate guide for extrapolating dosing for Apnea, and CX-1739 has similar insomnia-inducing ability as CX-717, we're still probably looking at a fair amount of insomnia side effect potential in our CX-1739 SA trial.
But there are other unknown variables too, which may outweigh all other factors. For example -- will the enhancement of sleep quality due to the improvement in apnea symptoms far outweigh any sleep interference due to the Ampakine?
Well, the only way to find out is to run the trial and see what happens. It'll be exciting to see these results.
Recent RSPI News
- Form 8-K - Current report • Edgar (US Regulatory) • 09/06/2024 12:45:11 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 08/02/2024 12:30:23 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 07/08/2024 08:01:32 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/29/2024 01:03:20 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/02/2024 01:30:27 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 01/22/2024 01:45:38 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 12/11/2023 01:45:18 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 11/17/2023 09:06:03 PM
- Form NT 10-Q - Notification of inability to timely file Form 10-Q or 10-QSB • Edgar (US Regulatory) • 11/14/2023 09:05:14 PM
SANUWAVE Announces Reverse Stock Split, Note and Warrant Exchange, and PIPE Offering • SNWV • Oct 18, 2024 9:31 AM
Vocodia Addresses Recent Stock Price Movement and Future Strategic Partnerships • VHAI • Oct 18, 2024 9:00 AM
Mass Megawatts Announces the Start of an Online Discount Solar Energy Equipment Business with Revenue Recognized for the First Time Since Year 2010 in this Fiscal Quarter • MMMW • Oct 18, 2024 7:32 AM
Unitronix Corp Advances DeFi Innovation with Tokenized Real-World Assets Integration • UTRX • Oct 17, 2024 7:38 AM
Mass Megawatts Commences Solar Energy Sales Efforts • MMMW • Oct 16, 2024 7:45 AM
SANUWAVE Health Announces 1-For-375 Reverse Stock Split • SNWV • Oct 16, 2024 7:40 AM