RespireRx Pharmaceuticals Inc (RSPI)

[davidal66]

I continue to believe that if the mechanism of ampakines upregulating the motor nucleus activity of cranial nerve 12(motor/tongue) works against sleep apnea, it should work in other more rarefied conditions. How about bulbar symptoms in motor neuron disease ALS? These folks often die so fast because of RD/aspiration et al, so ampakines could actually extend life in ALS patients simply by this specific mechanism of action. How about a bulbar predominant stroke in the brainstem/medulla? These folks die daily due to resp. depression/pneumonia et al. It is not such a clean issue as sleep apnea may be, since aspiration and apnea are two distinct things, but if you can improve tongue motor function, promoting a more normal breathing system, you could treat more neurological related conditions than simply sleep apnea. Ventilator weaning would be another sub acute treatment option. Thinking outside of the box, how about bulbar predominant myasthenia gravis?