RespireRx Pharmaceuticals Inc (RSPI)

[neuroinv]

Mea culpa. Actually I've had trouble logging on to the full pdf, and Nature acknowledges only that they've received my complaint. Looking at the abstract, it wasn't clear whether the "fragment" of APP (post BACE cleavage) had aggregated or not--but in thinking about it, probably not. So based on only partial access to the info, it looks like they are positing an extracellular locus for the 'event,' as opposed to intracellular effects from soluble AB. They are keeping BACE as the key cleavage event, which is disputed by some.

It's still a work in progress, and getting a lot of play considering that there is anything but consensus on the cleavage/molecule aggregation/locus combination that leads to AD.

But point taken--I was incorrect in referring to the plaque aspect.

NeuroInvestment