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Monday, January 12, 2009 9:17:13 PM
Re: Nucleoside vs Nucleotide (IDIX)
>What is the difference between a nucleotide polymerase inhibitor and
a nucleoside polymerase inhibitor?<
A nucleotide (right) consists of a nucleoside (left) and one-to-three
phosphate groups. (The depiction below contains one phosphate group.)
Why does this distinction matter?
The nucleotide with three phosphates is the active agent for all nucleoside/nucleotide drugs. IDIX found that a major reason for the failure of NM283, a nucleoside, was the variability of the phosphorylation step to produce the nucleotide from the nucleoside. With IDX184, this variability is eliminated because the prodrug resolves directly to the nucleotide in vivo.
>I believe IDIX has the only one of the former [nucleotide]<
This is correct as far as I know.
>What is the difference between a nucleotide polymerase inhibitor and
a nucleoside polymerase inhibitor?<
A nucleotide (right) consists of a nucleoside (left) and one-to-three
phosphate groups. (The depiction below contains one phosphate group.)
Why does this distinction matter?
The nucleotide with three phosphates is the active agent for all nucleoside/nucleotide drugs. IDIX found that a major reason for the failure of NM283, a nucleoside, was the variability of the phosphorylation step to produce the nucleotide from the nucleoside. With IDX184, this variability is eliminated because the prodrug resolves directly to the nucleotide in vivo.
>I believe IDIX has the only one of the former [nucleotide]<
This is correct as far as I know.
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