THE GREATEST STORY NEVER TOLD AGAIN PART 2
A small contribution---
COTARA-( I131 CH T.N.T.1/B ) is the fusion of a
radioactive particle-( iodine 131 ) and a monoclonal
antibody-( T.N.T. ). Radioactive iodine 131 gives off a
lethal burst of gamma rays within a 300 cell radius. The half life of I131 is approximately 8 days and it does not degrade off the antibody for approximately 10 days.
The Tumor Necrosis Targeting agent-( T.N.T. ) is the vehicle that carries iodine 131 to the cancer cells. because it is a chimeric antibody-( part mouse part human )allergic reactions are minimal. T.N.T. homes in on necrotic tissue found in the core of all solid based tumors. Cancer cells have leaky spots that allows
Cotara entrance-(normal cells do not ). Cotara is too large to fit through the outer membrane of a normal cell-( which also has some but relatively small amounts of necrotic tissue at its core ). Cotara is unique in that it is the only therapeutic agent that will attack ANY solid based tumor large enough to have a necrotic core and leave healthy tissue alone. Other monoclonal antibody therapies are geared for particular cancers - Cotara will seek out and deliver its deadly cargo to ALL solid based tumors.
Many monoclonal antibodies rely on finding and latching
on to specific docking sites found on the surface of cancer cells. If the antibody does not " overwhelm " the tumor then the disease is poised for a comeback. If the docking sites are used up and/or cell surface mutations have altered the sites then what at first appeared to be an effective modality will now be relatively useless. In contrast Cotara becomes more effective with each subsequent dose, since after each application more and more necrotic tissue forms thus presenting a larger and larger target.
Because our docking site is at the core of the tumor the problems associated with the lack of cell surface docking sites and/or mutations are eliminated.
Cotara does not merely interfere with cellular machinery. It is a powerful treatment that will incinerate more and more of the tumor from the inside out -( and send those toxic cells back into hell where they belong ).
According to Dr.Patel there has been some swelling associated with Cotara when used in treating a form of brain cancer. The problem was however manageable when steroids were used.
M.A.T.-( MODIFIED ANTIBODIES TECHNOLOGY) I copied this from an old Yahoo post. This is the "B" in
I131 CH T.N.T./B.
by: ownotshort (64/M/Seattle,WA) 07/19/99 01:20 pm
Msg: 27817 of 256647
" Techniclone scientists discovered that when a small organic molecule like the vitamin biotin is attached to a monoclonal antibody it decreases its electrical charge. Decreasing the electrical charge of the antibody dramatically influences the way the antibody travels in the blood stream. The positive electrical charge of an un-modified antibody gives it a sticky characteristic that causes it to stick to capillary walls as it passes through the blood stream. This stickiness causes delayed antibody circulation, decreased tumor uptake and increased antibody clearance time (time it takes the antibody and toxic payload to clear from the blood stream). Increased clearance time results in higher toxicity.
Decreasing the antibody clearance time may dramatically reduce the toxicity of many, if not most, monoclonal antibody/toxic drug therapies. The increase in monoclonal antibody uptake at the tumor site should result in an increase in drug efficacy. Monoclonal antibodies using TCLN s MAT clear from the bloodstream in half of the time of normal antibodies and produce a 2-3-fold increase in antibody/tumor uptake.
Wow, giving antibodies vitamins to pump them up ! A simple but very innovative idea that could be licensed to many companies developing monoclonal antibodies for therapy."
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This is but one tiny piece of what PPHM. has to offer.
Surely even this needs to be corrected, it definitely
needs to be augmented and refined. Putting everything together is a huge task but I know that the people on this board are capable of doing it.
That`s about all folks. IF your getting tired and frustrated of just talking and want to do something then maybe by completing this task your needs will be served, our share price might rise, and humanity will be rid of a dreaded disease.
I don't think anyone knows how effective Cotara can be in treating any and all solid tumors ( maybe the Chinese do ). I understand that trials need parameters but keep in mind that Cotara becomes more effective with each dose. It also has several advantages over Bavi:
1) It does not depend on the immune system for efficacy.
2) Even though Bavi can destroy tumor vasculature the tumor may still feed off the tissue near its periphery ---Cotara destroys tumors from the inside out.
3) Cotara has been approved for phase 3( albeit a different mode of delivery )
4) Cotara hasd been approved for "Orphan Drug and Fast Track " status.
Of course Cotara has radiation complications that Bavi doesn't but the focus should be on the possible synergestic effects achieveable when all of Tustin's tech is used together.
One last comment---I don't know how culpable Dr. Epstein is , but I would be fuming if my lifes work was in Tustin's hands---I HOPE Dr. Thorpe does not become disenchanted.
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This is but one tiny piece of what PPHM. has to offer.
Surely even this needs to be corrected, it definitely
needs to be augmented and refined. Putting everything together is a huge task but I know that the people on this board are capable of doing it.
That`s about all folks. IF your getting tired and frustrated of just talking and want to do something then maybe by completing this task your needs will be served, our share price might rise, and humanity will be rid of a dreaded disease
