RespireRx Pharmaceuticals Inc (RSPI)

[atheroprevent]

Haysaw, my replies are falling out of order, but I agree with Neuro.
>>3) Stoll has emphasized the clean cardio profile of CX717 in past CCs (comparing it to stimulant effects on heart rate, BP, etc.)<<

The main attraction of using ampakines in ADHD was the absence of cardiac stimulation vs amphetamines.

I would be much more concerned about an anatomic or morphologic change in cardiac structure, even if if just appeared as a fixation artifact. Small morphologic changes can add up to insidious failing of heart output over years or decades, hence the large n for clinical outcome study. For example in diabetics with MR spectroscopy we are now starting to find a buildup of triglicerides in heart muscle cell which may contribute to the high incidence of heart failure in diabetics. Other than infectious heart disease, most cardiomyopathies follow this pattern.

You are correct, Haysaw, we put up with the stimulatory side effects which mimic normal excursions of activity, but find no long term harm, as with caffeine. I do not have much experience with Modafinil.