Celexa V. Lexapro
"there are few, if any, randomized head-to-head studies of single-isomer drugs vs their parent racemates."
None to my knowledge. I asked to reinforce my personal and professional understanding that individual differences and subtle differences in metabolism/neurochemistry and/or side effects can make significant differences in efficacy for the arena of antidepressants.
With that said, imagine the difficulties involved in trying to convince either A) a PCP or B) an insurance medication program that there are indeed important differences not only at this level, but huge differences in efficacy in the broad range of antidepressants available.
Outside of my area of expertise, I'm certain the same argument can be forwarded for medications in different classes including for diabetes, seizure control, cardiac management etc.
aj
