jess,
re: Haynes paper in Virology -
It's true - Haynes discovery that during early HIV infection a quick accumulation of apoptotic debris (PS-exposing microparticles) stifles antibody production by B cells! was a VERY important discovery.
It changes everything. It's why Tony Fauci, (present head of NIAID, allocator of mucho HIV research moneys, and world-famous HIV researcher from the beginning), mentioned his new optimistic outlook... - basically, while it "raised the bar" in terms of what a successful vaccine will need to do, it also finally much more clearly elucidated what a successful vaccine will need to do. They now know what they're up against. That's what the paper discussed.
(Personally, I think Haynes recent findings were important in Fauci's July decision to ditch the PAVE-100 vaccine trial, since Haynes findings, regarding exposed PS, predict that only vaccines that (somehow :) "deal" with that exposed PS will work...).
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Here's an excerpt by Marilyn Chase who writes for the Wall St. Journal-
NIH’s Fauci Finds Hope Amid Challenges in AIDS Research
by Marilyn Chase
The NIH’s Anthony Fauci, who once cautioned that there might never be a traditional vaccine to prevent HIV infection and recently pulled the plug on a troubled vaccine trial, sounded a cautiously optimistic note at the 17th International AIDS Conference yesterday.
“The future for AIDS research looks bright and promising,” said Fauci, singling out recent work by Barton Haynes of Duke and Robert Siliciano of Johns Hopkins in illuminating how the virus hides inside the body and suppresses the immune system within days of infection.
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Here's Fauci's verbatim quote in Mexico City which Marilyn Chase was referring to -
NIAID Director Anthony Fauci, QUOTE from his Mexico City speech -
"A recent paper just a few days ago from Bart Haynes’ group in CHAVI and Duke showed that not only is a reservoir formed early, but byproducts of CD4 positive T-cell deaths increase significantly within days and are capable of suppressing the human immune response to the virus. So, we have a double whammy. We have a reservoir that almost immediately is formed and we have products of the death of cells suppressing the immune response that would hopefully prevent the establishment of that reservoir.
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By the way - in the paper (in the journal Virology) Haynes also cites and seems to agree with previous researchers (the ones I've been citing for two years! :) who have shown how exposed PS changes macrophage behavior, the cytokine environment, and T cells.
What remains to be seen is the work being done by Dr's Borrow and Bhardwaj into how the massive apoptotic debris (PS-exposing microparticles) in early HIV infection affects DENDRITIC CELLS.... (I'd expect to hear about their work soon ;).
(but I'll tell you, that Joel Shilyansky has already proven that PS-exposing microparticles screw up dendritic cells antigen-presenting abilities...)
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Meanwhile... Some Haynes patent applications recently became public on the WIPO and USPTO databases. They discuss HOW to do what we now know (thanks to Haynes Virology paper) needs to be done! :)
* Haynes now says that successful vaccines will need to BLOCK PS-MEDIATED IMMUNOSUPPRESSIVE SIGNALING. He suggests inducing anti-PS abs...
* In another patent applicaiton, Haynes now also suggests anti-PS mabs as HIV THERAPY for people infected with HIV!, - what looks to obviously be PEREGRINE'S anti-PS mab. (IS1, from Pojen Chen)...
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To sum up the present situation -
Haynes says that HIV vaccines will need to induce anti-PS abs.
Haynes says that anti-PS mabs should be successful THERAPY for people already infected with HIV.
Haynes specifically mentions IS1 as the safe therapeutic anti-PS mab for people already infected with HIV.
hang on a sec -
Q: THIS IS THE DIRECTOR OF CHAVI AND GATES RIGHT HAND MAN SAYING THIS????
A: YES, THAT'S RIGHT :).............
In the course of his recent papers and patent applications, Haynes mentions the following anti-PS mabs:
*Bavi
*Humanized Bavi
*Tarvi
*2AG4
*3G4
* IS1
*IS2
* IS6
They ALL seem to be Peregrine's.........
from both Thorpe, and Chen, who both contribute "CORE TECHNOLOGY" to the company....
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As for PAPERS with mentions of Peregrine's mabs, I expect one around the time of the Global HIV Vaccine Enterprise conference in October.
moby,
I expect it to mention, quite clearly, Peregrine's anti-PS, not as simply a testing reagent, but as a promising DRUG / THERAPY / TREATMENT FOR PEOPLE INFECTED WITH HIV, (as so clearly discussed in Haynes recent patent application).
It's happening :)
but hey -
Who's gonna pay for it?
Where will clinical trials take place?
LOL!
:)
j
AI
