Avid Bioservices Inc (CDMO)

[jazzbeerman]

carbon nanotubes + Bavi, to COOK tumors -----------

WIPO patent application published August 28, 2008 -

Targeting carbon nanotubes to exposed PS on tumor vasculature, and then cooking the tumor(s) by heating up the nanotubes..

Making specific mention of joining the Single-walled Nano-Tubes (SWNT) to a monoclonal anti-PS mab, (citing all Bavi/Thorpe patents) -



"The linking protein may be a phosphatidylserine-specific or other anionic phospholipid-specific monoclonal antibody to which the SWNT is complexed, conjugated or adsorbed or otherwise physically associated with methods known to those of ordinary skill in the art, for example using functionalized SWNTs. Examples of PS-specific monoclonal antibodies include those described in U.S. Patent Nos. 6,406,693; 6,818,213; 6,312,694; 6,783,760; 7,247,303; and PCT application WO2004/006847."



"After treatment with the protein-SWNT complex or peptide-SWNT complex of the present invention, the tumor having the SWNTs bound thereto is then selectively exposed to electromagnetic radiation, for example, near-infrared (NIR) radiation. NIR radiation causes excessive local heating of SWNTs but does not otherwise affect biological systems which are not associated to the SWNTs"


http://www.wipo.int/pctdb/en/fetch.jsp?ELEMENT_SET=B&IDB=0&LANG=ENG&IDOC=1508411&C=10&TOTAL=2978&START=1&QUERY=%28DE%2F11.31%29+&FORM=SEP-0%2FHITNUM%2CB-ENG%2CDP%2CMC%2CAN%2CPA%2CABSUM-ENG&TYPE_FIELD=256&SEARCH_IA=US2008002214&DISP=25&SERVER_TYPE=19-10&IA=US2008002214&RESULT=2&DBSELECT=PCT&SORT=41245759-KEY&DISPLAY=DESC

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j